4H-1-Benzopyran-3-carbonitrile, 2-aMino-5,6,7,8-tetrahydro-4-(4-Methoxyphenyl)-7-(1-naphthalenyl)-5-oxo-
UCPH-101
CAS: 1118460-77-7
Molecular Formula: C27H22N2O3
4H-1-Benzopyran-3-carbonitrile, 2-aMino-5,6,7,8-tetrahydro-4-(4-Methoxyphenyl)-7-(1-naphthalenyl)-5-oxo- - Names and Identifiers
4H-1-Benzopyran-3-carbonitrile, 2-aMino-5,6,7,8-tetrahydro-4-(4-Methoxyphenyl)-7-(1-naphthalenyl)-5-oxo- - Physico-chemical Properties
| Molecular Formula | C27H22N2O3 |
| Molar Mass | 422.48 |
| Density | 1.32±0.1 g/cm3(Predicted) |
| Melting Point | 194.0-197.2 °C |
| Boling Point | 703.5±60.0 °C(Predicted) |
| Solubility | DMSO : 100 mg/mL (236.70 mM; Need ultrasonic) |
| Appearance | solid |
| Color | Off-white |
| pKa | 3.23±0.60(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| Use | UCPH-101 is an inhibitor of excitatory amino acid transporter subtype 1 (EAAT1) with an IC50 value of 0.66 μM. |
| In vitro study | UCPH-101 and UCPH-102 inhibit EAAT1 anion currents in a concentration-dependent manner, with K D values of 0.34±0.03 μM (Hill=1.3±0.13, n≥9) for UCPH-101 and 0.17±0.02 μM (Hill=0.97±0.11, n≥7) for UCPH-102. A small but significant decrease in the total expression levels of both HA-EAAT1 and HA-GLAST is observed in cells preincubated with 100 μM UCPH-101 (p=0.048). |
4H-1-Benzopyran-3-carbonitrile, 2-aMino-5,6,7,8-tetrahydro-4-(4-Methoxyphenyl)-7-(1-naphthalenyl)-5-oxo- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.367 ml | 11.835 ml | 23.67 ml |
| 5 mM | 0.473 ml | 2.367 ml | 4.734 ml |
| 10 mM | 0.237 ml | 1.183 ml | 2.367 ml |
| 5 mM | 0.047 ml | 0.237 ml | 0.473 ml |
Last Update：2024-01-02 23:10:35
4H-1-Benzopyran-3-carbonitrile, 2-aMino-5,6,7,8-tetrahydro-4-(4-Methoxyphenyl)-7-(1-naphthalenyl)-5-oxo- - Reference Information
| biological activity | UCPH-101 is an inhibitor of the extractive amino acid transporter subtype 1 (EAAT1), the IC50 value determined by [3H]-EAAT1-HEK293 uptake assay in D-Asp cells was 0.66 μm. |
| Target | Value |
| EAAT1 (in EAAT1-HEK293 cells) | 0.66 μM |
Last Update：2024-04-10 22:29:15
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CAS: 1118460-77-7
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Product Name: UCPH-101 Visit Supplier Webpage Request for quotation
CAS: 1118460-77-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1118460-77-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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